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首页> 外文OA文献 >Impact of Virgin Olive Oil and Phenol-Enriched Virgin Olive Oils on the HDL Proteome in Hypercholesterolemic Subjects: A Double Blind, Randomized, Controlled, Cross-Over Clinical Trial (VOHF Study).
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Impact of Virgin Olive Oil and Phenol-Enriched Virgin Olive Oils on the HDL Proteome in Hypercholesterolemic Subjects: A Double Blind, Randomized, Controlled, Cross-Over Clinical Trial (VOHF Study).

机译：初榨橄榄油和富含酚的初榨橄榄油对高胆固醇血症患者HDL蛋白质组的影响：双盲，随机，对照，交叉临床试验（VOHF研究）。

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The effects of olive oil phenolic compounds (PCs) on HDL proteome, with respect to new aspects of cardioprotective properties, are still unknown. The aim of this study was to assess the impact on the HDL protein cargo of the intake of virgin olive oil (VOO) and two functional VOOs, enriched with their own PCs (FVOO) or complemented with thyme PCs (FVOOT), in hypercholesterolemic subjects. Eligible volunteers were recruited from the IMIM-Hospital del Mar Medical Research Institute (Spain) from April 2012 to September 2012. Thirty-three hypercholesterolemic participants (total cholesterol >200 mg/dL; 19 men and 14 women; aged 35 to 80 years) were randomized in the double-blind, controlled, cross-over VOHF clinical trial. The subjects received for 3 weeks 25 mL/day of: VOO, FVOO, or FVOOT. Using a quantitative proteomics approach, 127 HDL-associated proteins were identified. Among these, 15 were commonly differently expressed after the three VOO interventions compared to baseline, with specific changes observed for each intervention. The 15 common proteins were mainly involved in the following pathways: LXR/RXR activation, acute phase response, and atherosclerosis. The three VOOs were well tolerated by all participants. Consumption of VOO, or phenol-enriched VOOs, has an impact on the HDL proteome in a cardioprotective mode by up-regulating proteins related to cholesterol homeostasis, protection against oxidation and blood coagulation while down-regulating proteins implicated in acute-phase response, lipid transport, and immune response. The common observed protein expression modifications after the three VOOs indicate a major matrix effect. TRIAL REGISTRATION: International Standard Randomized Controlled Trials ISRCTN77500181.
机译：就心脏保护特性的新方面而言，橄榄油酚类化合物（PCs）对HDL蛋白质组的影响仍然未知。这项研究的目的是评估高胆固醇血症受试者摄入初榨橄榄油（VOO）和两个功能丰富的VOOs以及自己的PC（FVOO）或补充百里香PC（FVOOT）对HDL蛋白货物的影响。 。 2012年4月至2012年9月，从IMIM医院（西班牙）海洋医学研究所招募了合格的志愿者。33名高胆固醇血症参与者（总胆固醇> 200 mg / dL； 19名男性和14名女性；年龄35至80岁）在双盲，对照，交叉VOHF临床试验中随机分组。受试者接受3周25 mL /天的VOO，FVOO或FVOOT。使用定量蛋白质组学方法，鉴定出127种与HDL相关的蛋白。其中，三种VOO干预后与基线相比，通常有15种表达不同，每种干预观察到特定的变化。 15种常见蛋白主要涉及以下途径：LXR / RXR激活，急性期反应和动脉粥样硬化。所有参与者对这三个VOO的容忍度都很高。摄入VOO或富含苯酚的VOOs，通过上调与胆固醇稳态相关的蛋白质，防止氧化和血液凝结，同时下调与急性期反应，脂质相关的蛋白质，从而以心脏保护模式对HDL蛋白质组产生影响。运输和免疫反应。在三个VOO之后观察到的常见蛋白质表达修饰表明存在主要的基质效应。试用注册：国际标准随机对照试验ISRCTN77500181。

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